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Eukaryotic Cell, April 2006, p. 665-671, Vol. 5, No. 4
1535-9778/06/$08.00+0     doi:10.1128/EC.5.4.665-671.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Acanthamoeba castellanii Promotion of In Vitro Survival and Transmission of Coxsackie B3 Viruses

A. Mattana,1* C. Serra,2 E. Mariotti,1 G. Delogu,2 P. L. Fiori,2 and P. Cappuccinelli2

Department of Pharmaceutical Sciences,1 Department of Biomedical Sciences Division of Experimental and Clinical Microbiology, University of Sassari, 07100 Sassari, Italy2

Received 14 November 2005/ Accepted 18 January 2006

This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.

* Corresponding author. Mailing address: Dipartimento di Scienze del Farmaco, Via Muroni 23/A, 07100 Sassari, Italy. Phone: 39 79228744. Fax: 39 79228712. E-mail: dsfanto{at}uniss.it.

Eukaryotic Cell, April 2006, p. 665-671, Vol. 5, No. 4
1535-9778/06/$08.00+0     doi:10.1128/EC.5.4.665-671.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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Copyright © 2006 by the American Society for Microbiology.