Eukaryotic Cell
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Eukaryotic Cell, March 2008, p. 465-470, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00430-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Eighty Years after Its Discovery, Fleming's Penicillium Strain Discloses the Secret of Its Sex{triangledown} ,{dagger}

Birgit Hoff,1,{ddagger} Stefanie Pöggeler,2,{ddagger} and Ulrich Kück1*

Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Universitätsstr. 150, 44780 Bochum,1 Abteilung Genetik eukaryotischer Mikroorganismen, Institut für Mikrobiologie und Genetik, Georg-August Universität Göttingen, Grisebachstr. 8, 37077 Göttingen, Germany2

Received 28 November 2007/ Accepted 16 January 2008

Eighty years ago, Alexander Fleming discovered antibacterial activity in the asexual mold Penicillium, and the strain he studied later was replaced by an overproducing isolate still used for penicillin production today. Using a heterologous PCR approach, we show that these strains are of opposite mating types and that both have retained transcriptionally expressed pheromone and pheromone receptor genes required for sexual reproduction. This discovery extends options for industrial strain improvement programs using conventional genetical approaches.

* Corresponding author. Mailing address: Ruhr-Universität Bochum, Lehrstuhl für Allgemeine und Molekulare Botanik, Universitätsstr. 150, 44780 Bochum, Germany. Phone: 49 234 32 28212. Fax: 49 234 31 14184. E-mail: ulrich.kueck{at}ruhr-uni-bochum.de

{triangledown} Published ahead of print on 25 January 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

{ddagger} These authors contributed equally.

Eukaryotic Cell, March 2008, p. 465-470, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00430-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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