Eukaryotic Cell MMBR Online 2003
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EC Accepts, published online ahead of print on 11 April 2008
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Eukaryotic Cell doi:10.1128/EC.00066-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Contribution of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation and drug sensitivity in the opportunistic yeast Candida lusitaniae

Gwenaël Ruprich-Robert, Florence Chapeland-Leclerc, Stéphanie Boisnard, Martine Florent, Gaël Bories, and Nicolas Papon*

Programme Chimiorésistance des Levures Pathogènes, EA209 « Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance », UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France

* To whom correspondence should be addressed. Email: nicolas.papon{at}univ-paris5.fr.


  Abstract

We recently characterized the histidine kinase receptor genes of Candida lusitaniae. In the present study, we have further investigated the role of SSK1 and SKN7, encoding response regulators. Functional analysis of mutants indicated that Ssk1p is involved in osmotolerance and pseudohyphal development whereas Skn7p appears crucial for oxidative stress adaptation.




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