Eukaryotic Cell
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EC Accepts, published online ahead of print on 21 December 2007
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 Previous Article

Eukaryotic Cell doi:10.1128/EC.00437-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Regulation of Cryptococcus neoformans capsule size is mediated at the polymer level

Aki Yoneda and Tamara L. Doering*

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110

* To whom correspondence should be addressed. Email: doering{at}borcim.wustl.edu.


  Abstract

The fungal pathogen Cryptococcus neoformans regulates its polysaccharide capsule depending on environmental stimuli. To investigate whether capsule polymers change under different growth conditions, we analyzed shed capsule at physiological concentrations without physical perturbation. Our results indicate that regulation of capsule size is mediated at the level of individual polysaccharide molecules.






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