Eukaryotic Cell
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EC Accepts, published online ahead of print on 4 January 2008
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Eukaryotic Cell doi:10.1128/EC.00448-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Mathieu Gissot, Sang-Woon Choi, Reid F. Thompson, John M. Greally, and Kami Kim*

Departments of Medicine (Infectious Diseases) and Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.; Departments of Medicine (Hematology) and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA

* To whom correspondence should be addressed. Email: kkim{at}aecom.yu.edu.


  Abstract

Epigenetic factors play a role in expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of T.gondii and C. parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.




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