Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): The Spo5 dot colocalized with the Mei2 dot during meiotic prophase I of Schizosaccharomyces pombe. Cells that can express Spo5-green fluorescent protein (GFP) or Mei2-cyan fluorescent protein (CFP) were induced to enter meiosis, and the images for DNA (blue), Spo5-GFP (green), and Mei2-CFP (red) were obtained by fluorescence microscopy. When a single Spo5 dot was present in the cell (left columns), it colocalized with a single Mei2 dot in the nucleus, as demonstrated by the merged images (bottom panels). All cells carrying two Spo5 dots carry two Mei2 dots (right columns), and both of these dots colocalized with each other. (See related article on page 1301.)

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