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Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Hyphal formation is required for the full virulence potential of Candida albicans in a Caenorhabditis elegans infection model. C. albicans yeast cells are ingested into the intestine of the nematode. In liquid media, the yeast inside the worm undergo morphological change to form hyphae, which ultimately kills the animal. Hyphae are shown protruding from the mouth of a nematode infected with the C. albicans SSY50-B strain, a genetically modified fungus that allows the external manipulation of morphogenesis in vivo. The virulence of this strain toward C. elegans is increased when the assay is conducted under conditions that permit hyphal growth. (See related article on page 1750.)
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